The M6 Northbound carriageway is closed just before Junction 31 serving Preston and Clitheroe due to a tanker spillage.
All four lanes of the carriageway are closed and Police, Fire and Highways Agency are on the scene.
Police warn the road closures are likely to be in place for some time and are asking people to avoid travelling to the area if possible.
• Lancaster Travel Update site: www.traffic-update.co.uk/traffic/lancaster.asp